We examine the modes of action of each of these receptors, their expression, their role in aqueous humour production and outflow within the eye, as well as their roles as medications for the treatment of glaucoma.Įye g-protein coupled receptors glaucoma intraocular pressure ocular genetics prostaglandins. Prostaglandins (PGs) play a key role in the generation of the inflammatory response. In this review, we summarize the research into each of the prostaglandin molecules (PGD2, PGE2, PGF2, PGI2, TXA2) and their respective receptors (DP, EP1, 2, 3, 4, FP, IP). Background: Diclofenac is a proven, commonly prescribed nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, anti-inflammatory, and antipyretic properties, and has been shown to be effective in treating a variety of acute and chronic pain and inflammatory conditions. They share, to a greater or lesser degree, the same side effects, including gastric and renal toxicity. The currently used prostaglandin analogues (latanoprost, bimatoprost, tafluprost, and travoprost) mimic PGF2 and target one of the prostaglandin receptors (FP), though research into harnessing the other receptors using compounds like Sulprostone (EP3 receptor), or Iloprost (IP receptor) are currently ongoing. Nonsteroidal anti-inflammatory drugs (NSAIDs) produce their therapeutic activities through inhibition of cyclooxygenase (COX), the enzyme that makes prostaglandins (PGs). These drugs act by lowering intraocular pressure (IOP), a major risk factor for glaucoma. Prostaglandin inhibitors are drugs that inhibit the synthesis of prostaglandin in human body. ![]() ![]() may prevent fetal growth restriction through its inhibitory action on. Prostaglandin analogues are the front-line medications for the treatment of glaucoma, a condition resulting in blindness due to the death of retinal ganglion cells. prostaglandins with opposing regulatory effects on vascular homeostasis and. The prostaglandin precursors, arachidonic acid and the endoperoxide analog, U-44069, also stimulated the release of renin. Prostaglandins are small pro-inflammatory molecules derived from arachidonic acid that play roles in a multitude of biological processes including, but not limited to, inflammation, pain modulation, allergies, and bone formation.
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